Related Experiment Video
Updated: Jul 5, 2026

Using Cyclic Voltammetry, UV-Vis-NIR, and EPR Spectroelectrochemistry to Analyze Organic Compounds
Published on: October 18, 2018
Cyclic voltammetry of auranofin
A A Mohamed1, A E Bruce, M R Bruce
1Department of Chemistry University of Maine Orono Maine 04469-5706 USA.
Abstract:
The oxidative behavior of Auranofin, 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato- S(triethylphosphine)gold(I), was investigated by using cyclic voltammetry (CV) in 0.1 M Bu(4)NPF(6)/CH(2)Cl(2) and 0.1 M Bu(4)NPF(4)/CH(2)Cl(2) solutions using Pt working and auxiliary electrodes and a Ag/AgCI reference. CV studies at scan rates from 50-2,000 mV/s and Auranofin concentrations between 1 and 4 mM, show two irreversible oxidation processes occurring at +1.1 V and +1.6 V vs. Ag/AgCl. Ph(3) (p-thiocresolate) was also investigated as a reference for comparison of the oxidation processes in Auranofin to that of other phosphine gold thiolate complexes previously reported. The electrochemical response appears to be sensitive to adsorption at the electrode as well as to the nature of the supporting electrolyte solution. Repeated cycling shows a build up of products at the electrode.
Related Concept Videos
Voltammetric Techniques: Cyclic Voltammetry
Voltammetry: Overview
A voltammetric cell uses three electrodes: a working electrode, a reference electrode, and an auxiliary electrode. The redox reactions occur in the working...
Voltammetry: Factors Affecting Measurements
Voltammetric Techniques: Pulse Voltammetry
Voltammetry: Stripping Methods
Anodic Stripping Voltammetry (ASV)
ASV is used to determine metals and metalloids at trace levels. It involves two steps: deposition and stripping. First, a negative potential is applied to the...
Voltammetric Techniques: Linear-Scan (E vs Time)

