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Updated: Jul 5, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Cell damage at the origin of antiphospholipid antibodies and their pathogenic potential in recurrent pregnancy loss
V Piroux1, V Eschwège, J M Freyssinet
1Institut d'Hématologie et d'Immunologie Faculté de Médecine Université Louis Pasteur 4, rue Kirschleger Strasbourg 67085 France.
Abstract:
Antiphospholipid antibodies (APA) are associated with thrombosis, thrombocytopenia and fetal loss but they occur in a variety of diseases. Despite many efforts, a correlation between the specificity of particular subgroups of APA and particular clinical situations remains to be established. The antigens at the origin of APA remain to be identified. We discuss here the possible links between cell apoptosis or necrosis, leading to plasma membrane alterations, and the occurrence of APA in response to sustained stimulation. The pathogenic potential of APA is also considered with respect to recurrent pregnancy loss.
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