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[Relationship between the local invasion and the lymph node metastasis of the supraglottic carcinoma]
Weiliang Bai1, Wenyue Ji, Zhong Ren
1Department of Otolaryngology, Shengjing Hospital, China Medical University, Shenyang, 110004, China. bweiliang@yahoo.com.cn
Objective:
To explore the histopathology characteristics of supraglottic carcinoma with cervical lymph node metastasis.
Method:
Sixty-six specimens from patients with supraglottic laryngeal carcinoma were imbedded in collodion, made whole-organ serial section for HE staining, and observed under light microscope.
Result:
The rate of supraglottic carcinoma with lymph node metastasis invasion to pre-epiglottic space, supraglottic space and infraparaglottic space was 100.0% (18/18), 83.3% (15/18) and 44.4% (8/18) respectively, all of which were higher than that of supraglottic carcinoma with no lymph node metastasis (P < 0.05). The rate of supraglottic carcinoma with lymph node metastasis invasion to the whole pre-epiglottic space was 55.5% (10/18), and it was 29.1% (14/48) in supraglottic carcinoma without lymph node metastasis; there were significant differences between them (P < 0.05). The width and height of supraglottic carcinoma with lymph node metastasis invasion to supraglottic space was (7.4 +/- 5.2)mm, (11.6 +/- 7.6) mm, respectively. The width and height of the supraglottic carcinoma invasion to infraparaglottic space was (2.9 +/- 3.8) mm, (2.2 +/- 3.7) mm, respectively. Both of them were larger than that in supraglottic carcinoma with no lymph node metastasis (P < 0.05). For the supraglottic carcinoma with lymph node metastasis, the rate of the vocal cord fixation was 44.4% (8/18), which was significantly higher than that of supraglottic carcinoma without lymph node metastasis (P < 0.05).
Conclusion:
The supraglottic carcinoma with lymph node metastasis has special local invasion ability, and its important characteristics is the invasion to pre-epiglottic space and paraglottic space.
