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Updated: Jul 5, 2026

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
Published on: January 31, 2014
A collagen-binding mimetic of neural cell adhesion molecule
Hiroko Miyazaki1, Koichi Kato, Yuji Teramura
1Department of Reparative Materials, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Abstract:
A chimeric protein consisting of a cell-adhesive peptide derived from a neural cell adhesion molecule and a collagen-binding domain was synthesized using recombinant DNA technology. Here, we demonstrate that the chimeric protein binds to type I collagen and promotes the adhesion and neurite extension of hippocampus neurons. These results suggest that the chimeric protein has potential to provide microenvironments for neurons to adhere and survive in collagen-based matrices for use in cell-based therapies for central nervous disorders.
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