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Related Experiment Video

Updated: Jul 5, 2026

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
14:36

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

Photo-pH dually modulated fluorescence switch based on DNA spatial nanodevice.

Huajie Liu1, Yucheng Zhou, Yang Yang

  • 1National Centre for Nanoscience and Technology, Beijing, China.

The Journal of Physical Chemistry. B
|May 15, 2008
PubMed
Summary

We designed a novel molecular device integrating a fluorescent switch and DNA nanomachine. This system offers reversible control over fluorescence, mimicking Boolean logic operations for advanced molecular computing.

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Area of Science:

  • Molecular Engineering
  • Nanotechnology
  • Biophysics

Background:

  • Fluorescence resonance energy transfer (FRET) is crucial for molecular sensing.
  • DNA nanomachines offer precise spatial control for molecular devices.
  • Integrating light-responsive elements with DNA structures enables dynamic molecular systems.

Purpose of the Study:

  • To design and construct a novel molecular device.
  • To integrate a photoregulated fluorescent switch with a DNA nanomachine.
  • To achieve dual modulation of FRET for logic operations.

Main Methods:

  • Construction of a DNA-based nanomachine.
  • Integration of fluorescein and photochromic moieties.
  • Utilizing proton-driven mechanisms for spatial control.

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Last Updated: Jul 5, 2026

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
14:36

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

Spectroscopic Super-resolution Imaging of DNA Molecules using Intrinsic Contrast
09:19

Spectroscopic Super-resolution Imaging of DNA Molecules using Intrinsic Contrast

Published on: March 6, 2026

LED Thermo Flow — Combining Optogenetics with Flow Cytometry
05:49

LED Thermo Flow — Combining Optogenetics with Flow Cytometry

Published on: December 30, 2016

  • Characterization of distance-dependent FRET modulation.

    • Main Results:

    • Successful design and construction of the molecular device.
    • Demonstration of reversible switching of the device.
    • Modulation of FRET by the DNA nanomachine's spatial output.
    • Observation of fluorescence variation mimicking Boolean logic.

    Conclusions:

    • The novel molecular device exhibits reliable, reversible switching.
    • Dual modulation of fluorescence enables Boolean logic functions.
    • This work advances the development of sophisticated DNA-based molecular machines.