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Updated: Jul 5, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Estrogen and MYB in breast cancer: potential for new therapies

Thomas J Gonda1, Paul Leo, Robert G Ramsay

  • 1Professorial Research Fellow, Deputy Director and Head Cancer Biology Program, University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia. t.gonda@uq.edu.au

Expert Opinion on Biological Therapy
|May 15, 2008
PubMed

Insights

MYB is highly expressed in estrogen receptor-positive breast tumors and drives their proliferation. Targeting MYB offers a promising therapeutic strategy for breast cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Endocrinology

Background:

  • MYB is highly expressed in estrogen receptor (ER)-positive breast tumors.
  • MYB is a direct target of estrogen/ER signaling.
  • MYB is crucial for the proliferation of ER-positive breast cancer cell lines.

Purpose of the Study:

  • To discuss the rationale for targeting MYB therapeutically in breast cancer.
  • To explore potential anti-MYB therapeutic approaches.

Main Methods:

  • Review of recent studies on MYB expression and regulation in breast cancer.
  • Analysis of the mechanism of ER regulation of MYB.
  • Consideration of therapeutic strategies targeting MYB.

Main Results:

  • MYB expression is tightly regulated by estrogen/ER signaling in breast cancer.
  • MYB plays a critical role in the proliferation of ER-positive breast tumors.
  • Targeting MYB presents a viable therapeutic avenue.

Conclusions:

  • MYB is a key driver of ER-positive breast cancer proliferation.
  • Developing anti-MYB therapeutics is a rational approach for breast cancer treatment.
  • Further research into MYB-targeted therapies is warranted.

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