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Seborrheic keratosis that follows Blaschko's lines
Tomotaka Mabuchi1, Emiko Akasaka, Akio Kondoh
1Department of Dermatology, Tokai University School of Medicine, Kanagawa, Japan. mabuchi@is.icc.u-tokai.ac.jp
The Journal of Dermatology
|May 15, 2008
Summary
This study reports a rare case of seborrheic keratosis following Blaschko's lines in a 66-year-old man. The findings suggest a potential link between seborrheic keratosis and genetic mosaicism.
Area of Science:
- Dermatology
- Clinical Genetics
Background:
- Seborrheic keratosis is a common benign skin tumor.
- Blaschko's lines represent patterns of epidermal development and genetic mosaicism.
Observation:
- A 66-year-old man presented with asymptomatic, gradually enlarging keratotic papules on his trunk and left upper extremity.
- The lesions were arranged linearly along Blaschko's lines in an S-shape on the trunk and a straight line on the extremity.
Findings:
- Clinical and histopathological examination confirmed the diagnosis of seborrheic keratosis.
- The unique linear arrangement along Blaschko's lines is unprecedented in reported cases.
Implications:
- This case provides evidence supporting the hypothesis that seborrheic keratosis may arise from genetic mosaicism.
- Further research into the genetic basis of Blaschko-linear lesions is warranted.
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