Related Experiment Video
Updated: Jul 5, 2026
11:05
Behavioral Characterization of an Angelman Syndrome Mouse Model
Published on: October 20, 2023
Anaesthesia for Angelman syndrome.
K R Ramanathan1, D Muthuswamy, B J Jenkins
1Department of Anaesthetics, Prince Charles Hospital, Merthyr Tydfil, UK. krramanathan@yahoo.com
Anaesthesia
|May 15, 2008
Summary
Anesthesia administration in Angelman syndrome patients is safe. This condition involves chromosome 15 abnormalities affecting GABA receptors, crucial for anesthesia drugs.
Area of Science:
- Anesthesiology
- Genetics
- Neuroscience
Background:
- Angelman syndrome is a genetic disorder caused by abnormalities on chromosome 15.
- It affects the GABA receptor, a key target for many anesthetic agents.
- Understanding these implications is vital for safe patient care.
Observation:
- The study details the anesthetic management of a patient diagnosed with Angelman syndrome.
- The patient's specific genetic and neurological characteristics were considered during anesthetic planning.
- Close monitoring was implemented throughout the peri-operative period.
Findings:
- The administration of anesthesia to the Angelman syndrome patient proceeded without complications.
- The patient experienced an uneventful peri-operative course.
- Discharge occurred on the second postoperative day, indicating successful recovery.
Implications:
- This case highlights the feasibility of safe anesthesia in patients with Angelman syndrome.
- It suggests that current anesthetic practices can be effectively applied, even with GABA receptor involvement.
- Further research into anesthetic protocols for rare genetic disorders is warranted.
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