Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Galectin-3 gene silencing inhibits migration and invasion of human tongue cancer cells in vitro via downregulating β-Catenin.

Acta pharmacologica Sinica·2022
Same author

Ischemia preconditioning protects rat submandibular glands from ischemia/reperfusion injuries.

European journal of oral sciences·2014
Same author

Stable gene-silence of Kif2a synergistic with 5-fluorouracil suppresses oral tongue squamous cell carcinoma growth in vitro and in vivo.

Oral surgery, oral medicine, oral pathology and oral radiology·2013
Same author

[Gene expression of transforming growth factor beta receptor II in the epidermis of pathological scar].

Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns·2012
Same author

Galectin-3 gene silencing inhibits migration and invasion of human tongue cancer cells in vitro via downregulating β-catenin.

Acta pharmacologica Sinica·2012
Same author

Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells improves survival of ultra-long random skin flap.

Chinese medical journal·2011

Related Experiment Video

Updated: Jul 5, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Familial multiple odontogenic keratocysts.

Xu-Xia Wang1, Jun Zhang, Feng-Cai Wei

  • 1Department of Oral and Maxillofacial Surgery, Shandong University School of Stomatology, Jinan, Shandong, People's Republic of China.

Journal of Dentistry for Children (Chicago, Ill.)
|May 15, 2008
PubMed
Summary

Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin-Goltz syndrome, is characterized by multiple odontogenic keratocysts and specific facial features. Early diagnosis and genetic counseling are crucial for managing this autosomal dominant disorder.

More Related Videos

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
04:04

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Published on: August 15, 2025

Related Experiment Videos

Last Updated: Jul 5, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
04:04

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Published on: August 15, 2025

Area of Science:

  • Oral and Maxillofacial Surgery
  • Genetics
  • Dermatology

Background:

  • Nevoid basal cell carcinoma syndrome (NBCCS), or Gorlin-Goltz syndrome, is an autosomal dominant genetic disorder.
  • Multiple odontogenic keratocysts (OKCs) are a hallmark feature of NBCCS.
  • Recognition of NBCCS is vital due to its variable expressivity and significant clinical manifestations.

Observation:

  • The syndrome presents with characteristic facial anomalies, including macrocephaly, high-arched eyebrows, a broad nasal root, and mild hypertelorism.
  • Odontogenic keratocysts in the jaws are among the most frequent clinical findings in affected individuals.
  • This paper details a family case report illustrating NBCCS with multiple OKCs.

Findings:

  • Clinical, imaging, and histologic evaluations were used to identify the syndrome's features in the reported family.
  • The case highlights the importance of comprehensive assessment for diagnosing NBCCS.
  • Family history and literature review supplement the case presentation.

Implications:

  • Accurate diagnosis of NBCCS, both before and after therapy, is essential for patient management.
  • Genetic counseling and examination are recommended for affected families.
  • Understanding the multifaceted presentation of NBCCS aids in timely and appropriate clinical intervention.