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Limited Bedding and Nesting as a Model for Early-Life Adversity in Mice
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Early-life events. Effects on aging.

Eero Kajantie1

  • 1National Public Health Institute, Helsinki, Finland. eero.kajantie@helsinki.fi

Hormones (Athens, Greece)
|May 15, 2008
PubMed
Summary
This summary is machine-generated.

Early life conditions significantly influence lifelong health, impacting disease susceptibility. The Developmental Origins of Health and Disease (DOHaD) concept highlights critical intervention points for preventing age-related disorders.

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Area of Science:

  • Life Sciences
  • Medicine
  • Epidemiology

Background:

  • Emerging evidence links early-life exposures to lifelong health outcomes.
  • The Developmental Origins of Health and Disease (DOHaD) concept frames these long-term effects.
  • Understanding DOHaD is crucial for preventing age-related functional decline and disease.

Purpose of the Study:

  • To review epidemiological findings on early-life conditions and aging-related disorders.
  • To explore mechanisms linking early-life events to late-life disease.
  • To discuss the programming of the hypothalamic-pituitary-adrenal axis as a key mechanism.

Main Methods:

  • Synopsis of epidemiological studies.
  • Review of proposed biological mechanisms.
  • Focus on hypothalamic-pituitary-adrenal axis programming.

Main Results:

  • Early-life conditions are associated with increased susceptibility to aging-related diseases.
  • Cardiovascular disease, type 2 diabetes, depression, cognitive impairments, and osteoporosis are linked to early-life factors.
  • Hypothalamic-pituitary-adrenal axis programming is a well-characterized link.

Conclusions:

  • The DOHaD concept provides a framework for understanding lifelong health trajectories.
  • Interventions targeting early life may prevent age-related diseases.
  • Understanding programming mechanisms like HPA axis function is key for effective prevention strategies.