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Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

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Related Experiment Video

Updated: Jul 5, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

Aging and glycoxidant stress.

Melpomeni Peppa1, Jaime Uribarri, Helen Vlassara

  • 1Endocrine Unit, 2nd Dept of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Athens University, Medical School, Athens, Greece. molypepa@otenet.gr

Hormones (Athens, Greece)
|May 15, 2008
PubMed
Summary

Reducing dietary Advanced Glycation End products (AGEs) can combat aging-related oxidative stress and extend lifespan. A low-AGEs diet shows promise in human trials for reducing inflammation and oxidant burden.

Area of Science:

  • Gerontology
  • Nutritional Science
  • Oxidative Stress Research

Background:

  • Aging is linked to increased oxidative stress (OS) and accumulation of Advanced Glycation End products (AGEs).
  • Dietary AGEs (dAGEs) contribute to AGEs accumulation, receptor overload, and depleted antioxidant defenses.
  • Sustained exposure to dAGEs is a significant factor in aging and related diseases.

Purpose of the Study:

  • To review experimental data on the role of dAGEs in aging and related diseases.
  • To evaluate the impact of reducing dietary AGEs on OS, inflammation, and lifespan.
  • To explore the connection between modern dietary practices and age-related health conditions.

Main Methods:

  • Review of experimental animal and human studies.
  • Analysis of data from short-term human dietary intervention trials.

Related Experiment Videos

Last Updated: Jul 5, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

  • Consideration of ongoing long-term human studies.

    • Main Results:

    • Lowering dietary AGEs in mice extended lifespan and prevented age-related OS and AGEs accumulation.
    • Short-term human trials demonstrated that a low-AGEs diet reduces oxidant burden and inflammatory markers.
    • Evidence suggests a link between dAGEs and the progression of aging and associated diseases.

    Conclusions:

    • Reducing dietary AGEs is a viable strategy to mitigate aging-related OS and potentially extend lifespan.
    • A low-AGEs diet offers therapeutic potential for reducing inflammation and oxidative stress in humans.
    • Further long-term research is needed to confirm the causal relationship between Western diets and age-related diseases.