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Related Concept Videos

Peritoneum01:21

Peritoneum

The peritoneum is a vital membrane that lines the abdominal cavity and covers most of the organs within it. It plays a crucial role in protecting the organs, providing a smooth surface for their movement, and facilitating various physiological processes. Understanding the anatomy and function of the peritoneum is essential for comprehending the complexities of the abdominal region.
Anatomy of the Peritoneum
The peritoneum is divided into two layers: the parietal peritoneum and the visceral...
Enlargement of the Plasma Membrane01:22

Enlargement of the Plasma Membrane

Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...

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RAGE expression in the human peritoneal membrane.

Lars P Kihm1, Dennis Wibisono, Sandra Müller-Krebs

  • 1Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|May 15, 2008
PubMed
Summary
This summary is machine-generated.

Uraemic patients show increased peritoneal membrane damage, indicated by higher levels of advanced glycation end-products (AGE) receptor (RAGE) and inflammation markers. This damage, linked to AGE-RAGE interaction, worsens with peritoneal dialysis (PD) treatment.

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Area of Science:

  • Nephrology
  • Pathology
  • Molecular Biology

Background:

  • Experimental models link advanced glycation end-products (AGE) and receptor for AGE (RAGE) interaction to peritoneal damage.
  • This study investigates RAGE expression in the peritoneum of human patients with uraemia.

Purpose of the Study:

  • To examine the in vivo expression of RAGE and related markers in the peritoneal membrane of uraemic patients.
  • To assess changes in these markers over time, particularly after peritoneal dialysis (PD) treatment.

Main Methods:

  • Peritoneal biopsies from 89 subjects (48 uraemic, 41 healthy) were analyzed immunohistochemically for RAGE, inflammation, fibrosis, and angiogenesis markers.
  • Longitudinal analysis of 4 uraemic patients after 15 months of PD treatment included NFkappaB activity assessment via EMSA.

Main Results:

  • Uraemic patients exhibited significantly increased fibrosis, angiogenesis, submesothelial thickness, AGE accumulation (MGO adducts), RAGE, IL-6, VEGF, TGF-beta1, SMA, and NFkappaBp65 compared to controls.
  • Longitudinal follow-up revealed further increases in these parameters, especially RAGE expression and NFkappaB activation, after PD treatment.

Conclusions:

  • Uraemic peritoneum shows increased inflammation, angiogenesis, fibrosis, and AGE accumulation, with elevated RAGE expression and NFkappaB activity.
  • These findings support the critical role of AGE-RAGE interaction in uraemia-induced peritoneal damage, which is exacerbated by PD.