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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
Beta-papillomavirus infection and skin cancer
Jan Nico Bouwes Bavinck1, Elsemieke I Plasmeijer, Mariet C W Feltkamp
1Department of Dermatology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. j.n.bouwes_bavinck@lumc.nl
Abstract:
The development of highly sensitive PCR techniques and multiplex bead-based Luminex platforms has accelerated the search for a specific role of human papilloma viruses in the development of squamous cell carcinoma. Human papillomaviruses are most likely indirectly involved in this process by facilitating UV-related carcinogenesis via preventing UV-induced apoptosis or impairing DNA repair, but other mechanisms are also possible.
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