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Abnormal neuronal migration defect in the severe variant subtype of Adams-Oliver syndrome

Francesco Brancati1, Francesco Giuseppe Garaci, Rita Mingarelli

  • 1CSS IRCCS, Mendel Institute, Rome, Italy.

American Journal of Medical Genetics. Part A
|May 15, 2008
PubMed
Abstract

No abstract available in PubMed .

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...