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Updated: Jul 5, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Highly cooperative ion-pair recognition of potassium cyanide using a heteroditopic ferrocene-based crown
Hidekazu Miyaji1, Dae-Sik Kim, Byoung-Yong Chang
1Department of Chemistry and Center for Integrated Molecular Systems, POSTECH, San 31, Hyoja-dong, Pohang, 790-784, Republic of Korea.
Abstract:
A heteroditopic receptor having crown ether and trifluoroacetylcarboxanilide groups selectively recognizes both potassium and cyanide ions in acetonitrile with an association constant of as high as Ka = 1.9 x 10(7) M(-1) through a highly cooperative ion-pair interaction, resulting in two orders of magnitude enhancement in the binding affinity.
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