Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Protein Metabolism

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...

The Proteasome

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...

Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Child psychiatry: limited research, evidence for cost-effectiveness of treatment].

Tijdschrift voor psychiatrie·2016

Same author

The suitability of a single intertidal fish trap for the assessment of long-term trends in fish and epibenthic invertebrate populations.

Environmental monitoring and assessment·2013

Same author

Fetal loss in women with hereditary thrombophilic defects and concomitance of other thrombophilic defects: a retrospective family study.

BJOG : an international journal of obstetrics and gynaecology·2012

Same author

Policing: it pays the strong to protect the weak.

Trends in ecology & evolution·2011

Same author

Is extensive screening for cancer in idiopathic venous thromboembolism warranted?

Journal of thrombosis and haemostasis : JTH·2010

Same author

Bifurcation theory, adaptive dynamics and dynamic energy budget-structured populations of iteroparous species.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2010

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

Protein S deficiency: a clinical perspective.

M K ten Kate¹, J van der Meer

¹Division of Haemostasis, Thrombosis, and Rheology, Department of Hematology, University Medical Center Groningen, Groningen, The Netherlands.

Haemophilia : the Official Journal of the World Federation of Hemophilia

|May 16, 2008

Summary

Protein S deficiency increases the risk of venous thromboembolism (VTE) and fetal loss. Diagnosing this condition is challenging, leading to inconsistent findings regarding its role as a VTE risk factor.

More Related Videos

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

Related Experiment Videos

Last Updated: Jul 5, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

Area of Science:

Biochemistry
Hematology
Genetics

Background:

Protein S (PS) is crucial for down-regulating thrombin generation.
PS exists in plasma as both bound and free forms, complicating its study.
A pseudogene also contributes to the complexity of studying Protein S.

Purpose of the Study:

To present a clinical perspective on Protein S deficiency.
To address the diagnostic challenges associated with Protein S deficiency.
To clarify the role of Protein S deficiency in venous thromboembolism (VTE).

Main Methods:

Literature review focusing on clinical aspects of Protein S deficiency.
Analysis of existing studies on thrombophilia and Protein S.
Discussion of diagnostic methodologies and their limitations.

Main Results:

Protein S deficiency is linked to an increased risk of recurrent VTE and fetal loss.
Diagnostic difficulties have resulted in conflicting reports on PS as a VTE risk factor.
The complex nature of PS (pseudogene, bound/free forms) hinders accurate assessment.

Conclusions:

Accurate diagnosis of Protein S deficiency is critical for risk assessment.
Further research is needed to overcome diagnostic challenges.
Understanding Protein S deficiency is essential for managing thrombophilia and VTE risk.