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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Published on: September 6, 2017

Solid phase testing in the HLA laboratory: implications for organ allocation.

D D Eckels1

  • 1Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA. david.eckels@path.utah.edu

International Journal of Immunogenetics
|May 16, 2008
PubMed
Summary
This summary is machine-generated.

This provocative white paper challenges dogma in histocompatibility and immunogenetics testing. It highlights controversial issues in US transplantation and laboratory practices, urging international dialogue.

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Area of Science:

  • Histocompatibility and Immunogenetics
  • Transplantation Science
  • Clinical Laboratory Testing

Background:

  • Originally a white paper for the American Society for Histocompatibility and Immunogenetics (ASHI).
  • Considered too controversial for publication by ASHI leadership.
  • Intended to provoke discussion rather than review literature.

Purpose of the Study:

  • To present a controversial 'American point of view' on transplantation and laboratory testing.
  • To share critical issues facing US efforts with the international community.
  • To encourage open discussion and dissent from established dogma.

Main Methods:

  • Qualitative analysis of current practices and challenges.
  • Provocative argumentation and critical perspective.
  • Focus on issues in histocompatibility and immunogenetics.

Main Results:

  • Identified significant controversies in US transplantation and laboratory testing.
  • Highlighted the need for international perspectives on these issues.
  • Demonstrated that challenging established norms can be valuable.

Conclusions:

  • Dissent from dogma in histocompatibility and immunogenetics can be beneficial.
  • International collaboration is needed to address transplantation and testing challenges.
  • Open, spirited discussion is vital for scientific progress.