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Updated: Jul 5, 2026
03:10
A Rat Model of Compound Acne
Published on: November 1, 2024
Topical retinoids in acne--an evidence-based overview
Anja Thielitz1, Mohamed B Abdel-Naser, Joachim W Fluhr
1University Clinic of Dermatology, Otto-von-Guericke University Magdeburg, Germany.
Summary
Topical retinoids effectively manage acne by targeting comedones and inflammation. While all are effective, adapalene offers better tolerability compared to other topical retinoids like tazarotene and tretinoin.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Topical retinoids are crucial for acne management due to their action against comedones and anti-inflammatory properties.
- Approved topical retinoids include tretinoin, isotretinoin, adapalene, and tazarotene, with retinaldehyde used in cosmetics.
Purpose of the Study:
- To compare the efficacy and tolerability of various topical retinoids for acne treatment.
- To evaluate the safety profile and justify the use of topical retinoids in acne management.
Main Methods:
- Evidence-based review comparing efficacy and tolerability of different topical retinoids.
- Analysis of safety profiles, focusing on local adverse effects.
Main Results:
- Tazarotene 0.1% demonstrates higher efficacy than tretinoin or adapalene.
- Adapalene 0.1% shows comparable efficacy to tretinoin and isotretinoin.
- Adapalene 0.1% gel is better tolerated than tazarotene, tretinoin, and isotretinoin gels/creams, with common side effects being erythema, dryness, itching, and stinging.
Conclusions:
- Topical retinoids are effective as monotherapy for mild to moderate acne.
- Evidence supports the use of topical retinoids for most acne types and maintenance therapy.
- Adapalene offers a favorable balance of efficacy and tolerability.
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