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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

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Related Experiment Video

Updated: Jul 5, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

[Research progress on basal-like breast cancer].

Li-Ying Chen1, Hong-Feng Chen

  • 1Department of Breast Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People's Republic of China.

AI Zheng = Aizheng = Chinese Journal of Cancer
|May 16, 2008
PubMed
Summary

Breast cancer subtypes impact prognosis. The basal-like subtype, identified through gene expression, is linked to a poorer outlook, necessitating further research into its characteristics and treatment.

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Published on: November 8, 2014

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Last Updated: Jul 5, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres
09:49

Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres

Published on: November 8, 2014

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer is a leading global cancer in women.
  • Current prognosis relies on histopathology, but molecular markers offer predictive potential.
  • Gene expression profiling classifies invasive breast cancers into four subtypes: luminal A, luminal B, HER2 overexpressing, and basal-like.

Purpose of the Study:

  • To review the distribution of molecular subtypes in breast cancer.
  • To summarize current research on the characteristics of the basal-like breast cancer phenotype.
  • To discuss the prognostic implications of the basal-like subtype.

Main Methods:

  • Review of recent scientific literature on breast cancer molecular subtypes.
  • Analysis of gene expression profiling data for subtype classification.
  • Synthesis of research findings on basal-like phenotype characteristics and outcomes.

Main Results:

  • Invasive breast cancers are categorized into four distinct molecular subtypes based on gene expression.
  • The basal-like subtype is associated with a significantly poorer prognosis compared to other subtypes.
  • Understanding subtype distribution is crucial for personalized treatment strategies.

Conclusions:

  • Molecular subtyping provides critical prognostic information in breast cancer.
  • The basal-like subtype presents unique challenges due to its aggressive nature.
  • Further research into basal-like breast cancer is essential for improving patient outcomes.