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Updated: Jul 5, 2026

Screening for Amyloid Aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis
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Published on: July 16, 2008

Chaperone-dependent amyloid assembly protects cells from prion toxicity

Peter M Douglas1, Sebastian Treusch, Hong-Yu Ren

  • 1Department of Cell and Developmental Biology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599-7090, USA.

Proceedings of the National Academy of Sciences of the United States of America
|May 16, 2008
PubMed
Summary

Amyloid formation can be protective against protein toxicity. Molecular chaperones, like Sis1, can promote amyloid assembly to prevent cell death, challenging previous assumptions about protein aggregation.

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