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Prediabetes is associated with abnormal circadian blood pressure variability
A K Gupta1, F L Greenway, G Cornelissen
1Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA. guptaak@pbrc.edu
Journal of Human Hypertension
|May 16, 2008
Summary
Prediabetes is linked to abnormal blood pressure (BP) patterns, specifically abnormal circadian variability (ACV). A 7-day ambulatory BP monitoring (ABPM) study found prediabetics had significantly higher ACV, suggesting a link to cardiovascular disease risk.
Area of Science:
- Cardiovascular Health
- Endocrinology
- Chronobiology
Background:
- Blood pressure (BP) displays a circadian rhythm, crucial for cardiovascular health.
- Abnormal circadian variability (ACV) in BP is a known predictor of adverse cardiovascular disease (CVD) outcomes.
- Seven-day automatic ambulatory BP monitoring (ABPM) enables consistent identification of ACV.
Purpose of the Study:
- To investigate if healthy overweight individuals with prediabetes exhibit ACV compared to normoglycemic individuals.
- To assess differences in BP variability using 7-day ABPM between prediabetic and normoglycemic subjects.
Main Methods:
- Subjects with a family history of diabetes underwent 7-day ABPM.
- BP and heart rate were recorded every 30 minutes during the day and every 60 minutes at night.
- Chronobiologic interpretation of 7-day ABPM data was performed.
Main Results:
- Normoglycemic and prediabetic subjects were matched for key demographic and clinical factors, differing primarily in glucose levels.
- No ACV was found in normoglycemic individuals.
- Prediabetic subjects showed a significantly higher incidence of MESOR-hypertension, excessive pulse pressure, and circadian hyper-amplitude-tension (CHAT) (P<0.001).
Conclusions:
- Seven-day ABPM reveals a higher prevalence of abnormal circadian variability in prediabetic individuals.
- ACV identified through 7-day ABPM may contribute to the increased CVD risk observed in prediabetes.
- These findings support further research into the long-term predictive value of 7-day ABPM in prediabetes.
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