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Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
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The myelodysplastic/myeloproliferative neoplasms: myeloproliferative diseases with dysplastic features

A Orazi1, U Germing

  • 1Department of Pathology and Laboratory Medicine, Clarian Pathology Laboratory, Indiana University School of Medicine, Indianapolis, IN 46202, USA. aorazi@iupui.edu

Leukemia
|May 16, 2008
PubMed

Insights

The World Health Organization (WHO) has updated its classification of rare myeloid neoplasms, now termed myelodysplastic/myeloproliferative neoplasms (MDS/MPN). This review offers practical guidelines for reproducible classification of these uncommon disorders.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • The 2001 WHO classification defined myelodysplastic/myeloproliferative diseases (MDS/MPDs).
  • Upcoming WHO fascicle renames 'MPD' to 'myeloproliferative neoplasm (MPN)', thus 'MDS/MPD' becomes 'MDS/MPN'.
  • MDS/MPN encompasses chronic myelomonocytic leukemia, atypical chronic myeloid leukemia, juvenile myelomonocytic leukemia, and unclassifiable disorders.

Purpose of the Study:

  • To provide practical guidelines for the reproducible classification of myelodysplastic/myeloproliferative neoplasms (MDS/MPN).
  • To address the challenge that most MDS/MPN diseases are currently clinicopathologically assigned.
  • To facilitate accurate categorization of these rare myeloid neoplasms in clinical practice.

Main Methods:

  • Integration of bone marrow morphology.
  • Integration of peripheral blood morphology.
  • Incorporation of other laboratory and clinical findings into a multiparametric approach.

Main Results:

  • The review offers guidelines for classifying MDS/MPN.
  • The classification relies on a multiparametric approach.
  • This approach integrates morphology with clinical and laboratory data.

Conclusions:

  • Accurate classification of MDS/MPN requires a careful multiparametric approach.
  • The proposed guidelines aim for reproducible categorization of these rare neoplasms.
  • This review supports the updated WHO classification of myeloid neoplasms.

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