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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Related Experiment Video

Updated: Jul 5, 2026

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
17:13

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET

Published on: April 28, 2013

Gene expression profiling on acute rejected transplant kidneys with microarray.

Deping Li1, Kang Wang, Yong Dai

  • 1Hemopurification Department, Shenzhen People's Hospital, Shenzhen 518020, China.

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
|May 16, 2008
PubMed
Summary

Early diagnosis of acute kidney transplant rejection may require a panel of gene markers, not a single one. Interferon-gamma-induced GTPase (IGTP) gene expression is significantly upregulated during rejection.

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A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
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A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

Related Experiment Videos

Last Updated: Jul 5, 2026

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
17:13

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET

Published on: April 28, 2013

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
07:01

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

Area of Science:

  • Immunology
  • Genetics
  • Transplantation

Background:

  • Acute allograft rejection poses a significant challenge in renal transplantation.
  • Identifying early diagnostic markers is crucial for timely intervention and improved patient outcomes.

Purpose of the Study:

  • To investigate gene expression profiles during acute allograft rejection in a rat model.
  • To identify potential molecular markers for the early diagnosis of acute renal transplant rejection.

Main Methods:

  • Heterotopic kidney transplantation was performed in a rat model without immunosuppression.
  • Renal grafts were harvested at 3, 7, and 14 days post-transplantation.
  • Gene expression levels were analyzed using commercial microarrays on day-7 grafts.

Main Results:

  • 48 genes showed upregulated expression in allografts compared to isografts.
  • Interferon-gamma-induced GTPase (IGTP) gene was the most significantly upregulated.
  • Acute rejection involves dynamic, non-balanced pathways with multiple contributing factors.

Conclusions:

  • IFN-inducible genes, like IGTP, may play a critical role in acute allograft rejection.
  • Early diagnosis of acute rejection is unlikely with a single gene marker.
  • A combination of gene markers could enable early diagnosis of acute renal transplant rejection.