Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Variable receptor affinity and tissue sensitivity.

M A Oriowo1, R D Bevan, J A Bevan

  • 1Department of Pharmacology, University of Vermont, College of Medicine, Burlington.

Blood Vessels
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cyclic Adenosine Monophosphate-Mediated Enhancement of Vascular Endothelial Growth Factor Released by Differentiated Human Monocytic Cells: The Role of Protein Kinase A.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre·2015
Same author

Expression of alternatively spliced variants of Na-Ca-exchanger-1 in experimental colitis: role in reduced colonic contractility.

Molecular and cellular biochemistry·2012
Same author

TH-9 (a theophylline derivative) induces long-lasting enhancement in excitatory synaptic transmission in the rat hippocampus that is occluded by frequency-dependent plasticity in vitro.

Neuroscience·2012
Same author

Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis.

Molecular and cellular biochemistry·2008
Same author

Indications of the mechanisms involved in improved sperm parameters by zinc therapy.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre·2008
Same author

Mechanism underlying the reversal of contractility dysfunction in experimental colitis by cyclooxygenase-2 inhibition.

Inflammopharmacology·2006
Same journal

Interaction of vascular alpha-1 adrenoceptors with multiple signal transduction pathways.

Blood vessels·1991
Same journal

Effect of papaverine on endothelial cell harvest from canine external jugular veins.

Blood vessels·1991
Same journal

Postischemic cerebral blood flow and neuroeffector mechanisms.

Blood vessels·1991
Same journal

Innervation and effects of dilatory neuropeptides on cerebral vessels. New aspects.

Blood vessels·1991
Same journal

Release of vasoactive peptides from autonomic and sensory nerves.

Blood vessels·1991
Same journal

Spatial and temporal resolution of serotonin-induced changes in intracellular calcium in a cultured arterial smooth muscle cell line.

Blood vessels·1991
See all related articles

Vascular smooth muscle sensitivity to norepinephrine (NE) varies due to alpha 1-adrenoceptor affinity, not just number. A microenvironment factor influences NE receptor affinity and tissue response.

Area of Science:

  • Pharmacology
  • Physiology
  • Molecular Biology

Background:

  • Vascular smooth muscle sensitivity to norepinephrine (NE) exhibits significant inter-arterial and inter-species variation.
  • This variation is crucial for understanding blood pressure regulation and vascular tone.

Purpose of the Study:

  • To investigate the determinants of varying vascular smooth muscle sensitivity to norepinephrine (NE).
  • To explore the roles of alpha 1-adrenoceptor affinity and number in modulating NE sensitivity.

Main Methods:

  • In vitro contractile responses of various rabbit arteries to norepinephrine.
  • Assessment of norepinephrine (NE) binding affinity to alpha 1-adrenoceptors.
  • Solubilization and reconstitution of alpha 1-adrenoceptors to study microenvironmental effects.

Related Experiment Videos

Main Results:

  • A strong correlation was observed between NE's alpha 1-adrenoceptor affinity and tissue sensitivity.
  • Receptor microenvironment factors were found to modulate ligand affinity.
  • Receptor number showed a weaker correlation with NE sensitivity compared to affinity.

Conclusions:

  • Vascular smooth muscle sensitivity to NE is primarily modulated by alpha 1-adrenoceptor affinity, influenced by the receptor's microenvironment.
  • The observed continuous variation suggests a single receptor population rather than distinct subtypes.
  • Receptor-associated factors play a significant role in regulating vascular responsiveness to norepinephrine.