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Related Concept Videos

Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Seizures ll: Types01:19

Seizures ll: Types

Seizures are sudden bursts of abnormal electrical discharge in the brain that interfere with normal function. They are commonly divided into three groups: focal seizures, generalized seizures, and other types that do not fit neatly into either category.Focal SeizuresFocal seizures begin in a single brain region. When awareness is preserved, they are called focal aware seizures and may cause sensations such as tingling, unusual smells, or flashing lights. When awareness is impaired, they are...

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Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
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Published on: September 20, 2024

Postictal psychosis in partial epilepsy: a case-control study.

Kenneth Alper1, Ruben Kuzniecky, Chad Carlson

  • 1Department of Neurology, Comprehensive Epilepsy Center, New York, NY 10016, USA. kra1@nyu.edu

Annals of Neurology
|May 16, 2008
PubMed
Summary
This summary is machine-generated.

Postictal psychosis (PIP) in partial epilepsy is linked to widespread brain activity, family history of psychiatric issues and epilepsy, and prior encephalitis. These factors increase the risk of developing PIP.

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Published on: July 8, 2025

Area of Science:

  • Neurology
  • Psychiatry
  • Epilepsy Research

Background:

  • Postictal psychosis (PIP) is a complex neuropsychiatric complication following seizures.
  • Previous studies on PIP risk factors have yielded inconsistent results.
  • A controlled study with a substantial patient cohort is needed to clarify these associations.

Purpose of the Study:

  • To identify and analyze the correlates of risk for postictal psychosis (PIP) in patients with partial epilepsy.
  • To differentiate risk factors in patients with and without a history of PIP.
  • To provide a clearer understanding of the underlying domains contributing to PIP development.

Main Methods:

  • A consecutive series of 59 patients with partial epilepsy and a history of PIP were compared with 94 control patients with partial epilepsy and no PIP history.
  • Video-electroencephalography (VEEG) was used for inpatient evaluation.
  • Statistical analyses included exact tests, principal components analysis, and logistic regression to evaluate risk variables.

Main Results:

  • PIP was significantly associated with extratemporal or undetermined seizure onset, bilateral epileptiform activity, and secondary generalization.
  • A history of encephalitis and family histories of psychiatric disorders and epilepsy were identified as significant risk factors.
  • A risk score based on nine independent variables demonstrated a strong association with PIP, increasing the odds ratio by 1.71 per unit increase.

Conclusions:

  • Postictal psychosis in partial epilepsy is associated with broadly distributed epileptogenic networks.
  • Genetic factors contributing to psychiatric disorders and epilepsy play a role in PIP.
  • Encephalitis is a notable risk factor for the development of postictal psychosis.