Controlled release scaffolds for bone tissue engineering
Related Experiment Video
Updated: Jul 5, 2026
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
Published on: September 11, 2015
1Institute of Science and Technology in Medicine, University of Keele, Medical Research Unit, Hartshill, Stoke-on-Trent, Staffordshire, United Kingdom. s.h.cartmell@keele.ac.uk
Abstract:
Bone disease and trauma can sometimes create defects that require more than current clinical therapies can provide for effective healing. Scaffolds that release bioactive agents such as drugs offer additional benefits in this regard in comparison to those whose main requirements are space filling and load bearing. This review details a variety of recent research on scaffold carrier systems that release osteogenic drugs for orthopaedic treatment purposes. The controlled release scaffolds presented are created from a variety of materials (such as tricalcium phosphate, hydrogel systems and poly(D,L-lactide)) and release drugs such as statins, bisphosphonates and a variety of growth factors.
