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Related Experiment Video

Updated: Jul 5, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

Selenium attenuates pro-inflammatory gene expression in macrophages.

Hema Vunta1, Benjamin J Belda, Ryan J Arner

  • 1Department of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis and Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, PA 16801, USA.

Molecular Nutrition & Food Research
|May 16, 2008
PubMed
Summary

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Selenium and Selenoproteins in Neutrophil Functions.

Biological trace element research·2025

Selenium (Se) is vital for immune function. This study shows Se supplementation reduces inflammation by inhibiting pro-inflammatory genes in macrophages, highlighting its role in immune regulation.

Area of Science:

  • Immunology
  • Nutritional Biochemistry

Background:

  • Selenium (Se) is essential for immune system function, particularly in macrophages.
  • Selenoproteins, Se-dependent antioxidants, protect against reactive oxygen species.

Purpose of the Study:

  • To investigate Se's role as an anti-inflammatory agent.
  • To determine Se's effect on macrophage signaling pathways activated by lipopolysaccharide (LPS).

Main Methods:

  • Supplementation of Se to Se-deficient macrophages.
  • Analysis of pro-inflammatory gene expression (COX-2, TNF-alpha) and MAP kinase pathways.
  • Assessment of macrophage infiltration in LPS-treated mice.

Main Results:

  • Se supplementation significantly decreased LPS-induced COX-2 and TNF-alpha expression in macrophages.

Related Experiment Videos

Last Updated: Jul 5, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

  • Se inhibited LPS-mediated MAP kinase pathways.
  • Se deficiency exacerbated LPS-induced macrophage infiltration in mouse lungs.

    • Conclusions:

    • Selenium acts as an anti-inflammatory agent by regulating pro-inflammatory gene expression in immune cells.
    • Host Se status is a critical factor in modulating inflammation.
    • Se is crucial for maintaining immune homeostasis and mitigating inflammatory responses.