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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...

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Updated: Jul 5, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Assessing the current role of platelet function testing.

Eugene Braunwald1, Dominick Angiolillo, Eric Bates

  • 1TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 350 Longwood Avenue, Boston, Massachusetts 02115, USA. ebraunwald@partners.org

Clinical Cardiology
|May 20, 2008
PubMed
Summary
This summary is machine-generated.

Standardized platelet function tests are used in research but yield conflicting results for predicting patient response to antiplatelet therapy like aspirin or clopidogrel. Clinical guidance for hyporesponsive patients and standardized resistance definitions are currently lacking.

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Published on: February 14, 2017

Area of Science:

  • Cardiovascular Research
  • Clinical Pharmacology
  • Hematology

Background:

  • In vitro platelet function tests are frequently utilized in research to support antiplatelet therapy.
  • Existing studies show inconsistent results regarding the predictive capability of standardized tests for clinical response to aspirin and clopidogrel.

Purpose of the Study:

  • To evaluate the utility of standardized platelet function tests in predicting clinical response to antiplatelet agents.
  • To highlight the lack of standardized definitions for antiplatelet resistance and the unknown treatment for hyporesponsive patients.

Main Methods:

  • Review of studies assessing standardized platelet function tests.
  • Analysis of contradictory findings on predicting clinical response to aspirin and clopidogrel.

Main Results:

  • Contradictory results exist regarding the ability of standardized platelet function tests to predict clinical response to aspirin or clopidogrel.
  • There is no established definition for antiplatelet therapy resistance or a known treatment strategy for hyporesponsive patients.

Conclusions:

  • While useful in research, the role of platelet function tests in guiding clinical therapy is not yet established.
  • Prospective trials are urgently needed to define the clinical utility of these tests.
  • An ideal test for clinical practice should be rapid, easy-to-use, inexpensive, and reliable.