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14-3-3 proteins: a family of versatile molecular regulators
V Obsilová1, J Silhan, E Boura
1Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic. obsil@natur.cuni.cz
Abstract:
The 14-3-3 proteins are a family of acidic regulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. Through the functional modulation of a wide range of binding partners, 14-3-3 proteins are involved in many processes, including cell cycle regulation, metabolism control, apoptosis, and control of gene transcription. This minireview includes a short overview of 14-3-3 proteins and then focuses on their role in the regulation of two important binding partners: FOXO forkhead transcription factors and an enzyme tyrosine hydroxylase.
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