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Related Experiment Video

Updated: Jul 5, 2026

Use of Drosophila S2 Cells for Live Imaging of Cell Division

Use of Drosophila S2 Cells for Live Imaging of Cell Division

Published on: August 23, 2019

Cell division screens and dynamin.

Mary Kate Bonner¹, Ahna R Skop

¹Department of Genetics, University of Wisconsin-Madison, 425-G Henry Mall, Madison, WI 53706, USA. mbonner@wisc.edu

Biochemical Society Transactions

|May 17, 2008

Summary

Cell division is crucial for organism development and repair. This review explores the multifaceted roles of the conserved protein dynamin in mitosis, clarifying its cell cycle functions and targets.

Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

Cell division is fundamental for development, repair, and stem cell maintenance.
Studying cell division (mitosis) is challenging due to its dynamic nature and transient protein expression.
Proteomics and specific inhibitors have identified key cell cycle factors, including dynamin.

Purpose of the Study:

To review current knowledge on cell division screens and their impact.
To elucidate the precise cell cycle functions of the protein dynamin.
To identify upstream and downstream targets of dynamin during mitosis.

Main Methods:

Analysis of data from cell division screens.
Review of existing literature on dynamin's roles.

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Last Updated: Jul 5, 2026

Use of Drosophila S2 Cells for Live Imaging of Cell Division

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Published on: August 23, 2019

Time-lapse Imaging of Mitosis After siRNA Transfection

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Integration of findings from proteomics and inhibitor studies.

Main Results:

Dynamin, known for endocytosis, is implicated in coordinating actin assembly at membranes.
Several cell division screens have identified dynamin as a crucial factor.
The exact mitotic functions and regulatory pathways of dynamin remain incompletely understood.

Conclusions:

Dynamin plays multiple, yet unclear, roles during mitosis.
Further research is needed to fully understand dynamin's cell cycle regulation and targets.
This review consolidates current understanding and highlights knowledge gaps regarding dynamin in cell division.