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Related Concept Videos

Distribution of Cytoplasmic Content02:33

Distribution of Cytoplasmic Content

Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of small...
Centrioles and Centrosomes01:13

Centrioles and Centrosomes

Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or "prometaphase,"...
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis And Cytokinesis01:35

Mitosis And Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...

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Related Experiment Video

Updated: Jul 5, 2026

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets
10:52

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets

Published on: August 13, 2016

Endosome positioning during cytokinesis.

Guillaume Montagnac1, Philippe Chavrier

  • 1Institut Curie, Centre de Recherche, Paris F-75248 France. guillaume.montagnac@curie.fr

Biochemical Society Transactions
|May 17, 2008
PubMed
Summary

Cell division requires recycling membranes delivered to the midbody. This study explores how endosomes cluster at specific cell division sites, crucial for membrane delivery during cytokinesis.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cytokinesis, the final stage of cell division, depends on precise membrane trafficking.
  • Recycling endosomes cluster at the mitotic spindle poles and midbody during mammalian cell cytokinesis.
  • The mechanisms governing endosome positioning during cytokinesis remain largely unknown.

Purpose of the Study:

  • To investigate the mechanisms controlling endosome clustering during cell division.
  • To understand the role of endosomal clusters in membrane delivery to the midbody.
  • To elucidate the importance of endosome positioning for successful cytokinesis.

Main Methods:

  • This study is a discussion and review of existing literature and proposed mechanisms.
  • It synthesizes current knowledge on endosome dynamics and cell division.

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Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

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Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

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Last Updated: Jul 5, 2026

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets
10:52

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets

Published on: August 13, 2016

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
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Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

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  • Focuses on theoretical frameworks for endosome organization.

    • Main Results:

    • Endosomal clusters are proposed to form through interactions with cytoskeletal elements and motor proteins.
    • These clusters are essential for concentrating recycling membranes at the site of cell separation.
    • Proper positioning ensures efficient membrane addition for midbody formation and abscission.

    Conclusions:

    • Understanding endosome clustering mechanisms is vital for comprehending cytokinesis completion.
    • Targeted membrane delivery to the midbody, mediated by endosomal clusters, is a critical step in cell division.
    • Further research into the molecular players involved in endosome positioning is warranted.