Related Experiment Video
Updated: Jul 5, 2026

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
Published on: January 24, 2016
Targeting IRFs by ubiquitination: regulating antiviral responses
Rowan Higgs1, Caroline A Jefferies
1Molecular and Cellular Therapeutics and RSCI Research Institute, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.
Abstract:
The IRF [IFN (interferon) regulatory factor] family of transcription factors control many cellular processes, including induction of key antiviral cytokines, type I IFNs, following viral infection. Recent studies have revealed several endogenous and viral proteins involved in ubiquitin-mediated regulation of IRF activity and thus having an impact on type I IFN signalling. Through the ubiquitin pathway, these proteins can manipulate the antiviral response either by initiating proteasomal degradation of the IRFs or, in contrast, by promoting activation of the IRFs.
More Related Videos
Related Concept Videos
Inhibitors of Viral Protein Synthesis
Regulation of the Unfolded Protein Response
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Inhibitors Of Virion Release
Antiviral Nucleoside Inhibitors
siRNA - Small Interfering RNAs
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...

