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Regulation of gene expression by the RNA-binding protein Sam68 in cancer

Prabhakar Rajan1, Luke Gaughan, Caroline Dalgliesh

  • 1Institute of Human Genetics, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK. prabs_rajan@yahoo.co.uk

Biochemical Society Transactions
|May 17, 2008
PubMed

Insights

Sam68, a key RNA-binding protein, regulates gene expression through transcription and RNA processing. This review highlights its crucial roles in cancer development and progression.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • RNA Biology

Background:

  • Sam68 (Src-associated in mitosis 68 kDa) is a STAR family RNA-binding protein.
  • It participates in diverse cellular functions like signal transduction, transcription, RNA metabolism, cell cycle, and apoptosis.

Purpose of the Study:

  • To review the functions of Sam68.
  • To highlight its roles as a transcriptional and post-transcriptional regulator of gene expression.
  • To emphasize its relevance in cancer.

Main Methods:

  • Literature review of Sam68 functions.
  • Analysis of Sam68's regulatory mechanisms in gene expression.
  • Focus on cancer-related studies involving Sam68.

Main Results:

  • Sam68 acts as both a transcriptional and post-transcriptional regulator.
  • Its functions are critical in various cellular processes.
  • Sam68 plays a significant role in the context of cancer.

Conclusions:

  • Sam68 is a versatile regulator of gene expression.
  • Understanding Sam68's functions is vital for cancer research.
  • Further investigation into Sam68's mechanisms may reveal therapeutic targets.

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