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Updated: Jul 5, 2026

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
Published on: November 11, 2014
The use of Affymetrix GeneChips as a tool for studying alternative forms of RNA
Andrew P Harrison1, Joanna Rowsell, Renata da Silva Camargo
1Departments of Biological Sciences and Mathematical Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK. harry@essex.ac.uk
Abstract:
We are developing a computational pipeline to use surveys of Affymetrix GeneChips as a discovery tool for unravelling some of the biology associated with post-transcriptional processing of RNA. This work involves the integration of a number of bioinformatics resources, from comparing annotations to processing images to determining the structure of transcripts. The rapidly growing datasets of GeneChips available to the community puts us in a strong position to discover novel biology about post-transcriptional processing, and should enable us to determine the mechanisms by which some groups of genes make co-ordinated changes in their production of isoforms.
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