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Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
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Published on: June 18, 2018

Gait dysfunction in mild cognitive impairment syndromes.

Joe Verghese1, Matthew Robbins, Roee Holtzer

  • 1Department of Neurology, Einstein Aging Study, Albert Einstein College of Medicine, Bronx, New York 10461, USA. jverghes@aecom.yu.edu

Journal of the American Geriatrics Society
|May 17, 2008
PubMed
Summary

Gait problems are common in older adults with mild cognitive impairment (MCI). Both amnestic MCI and nonamnestic MCI subtypes show worse gait performance compared to healthy controls.

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Area of Science:

  • Gerontology
  • Neurology
  • Biomedical Engineering

Background:

  • Mild cognitive impairment (MCI) affects older adults, impacting daily function.
  • Gait disturbances are increasingly recognized as potential early indicators of cognitive decline.

Purpose of the Study:

  • To systematically assess gait in older adults with amnestic MCI (a-MCI) and nonamnestic MCI (na-MCI).
  • To compare gait performance between MCI subtypes and cognitively normal individuals.

Main Methods:

  • A cross-sectional study involving 54 a-MCI, 62 na-MCI, and 295 healthy controls from the Einstein Aging Study.
  • Clinical and quantitative gait assessments were performed.
  • Factor analysis identified gait domains: pace, rhythm, and variability.

Main Results:

  • Neurological gait abnormalities were more frequent in a-MCI than controls.
  • Both MCI subtypes exhibited poorer quantitative gait across multiple parameters compared to controls.
  • a-MCI subjects had worse rhythm and variability; na-MCI subjects had poorer pace.
  • MCI individuals with gait abnormalities reported higher disability.

Conclusions:

  • Gait dysfunction is prevalent in both amnestic and nonamnestic subtypes of mild cognitive impairment in older adults.
  • Specific gait patterns (rhythm, variability, pace) differ between MCI subtypes.
  • Gait abnormalities are associated with increased disability in MCI.