Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple sclerosis in black children.

N Zelnik1, A D Gale, S A Shelburne

  • 1Department of Neurology, Children's Hospital National Medical Center, Washington, DC.

Journal of Child Neurology
|January 11, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic Analysis of Mobile Genetic Elements Mediating β-Lactamase Gene Amplification in Noncarbapenemase-Producing Carbapenem-Resistant <i>Enterobacterales</i> Bloodstream Infections.

mSystems·2022
Same author

Whole-genome sequencing of Staphylococcus epidermidis bloodstream isolates from a prospective clinical trial reveals that complicated bacteraemia is caused by a limited number of closely related sequence types.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
Same author

Fetal paroxysmal supraventricular tachycardia without heart failure leading to ischemic damage.

Prenatal diagnosis·2006
Same author

Seizure control and educational outcome in childhood-onset epilepsy.

Journal of child neurology·2001
Same author

Clinical manifestations of psychiatric patients who are carriers of tay-sachs disease. Possible role of psychotropic drugs.

Neuropsychobiology·2000
Same author

Sleep patterns in autistic children.

Journal of autism and developmental disorders·1999
Same journal

Birmingham, 1963.

Journal of child neurology·2026
Same journal

Hyperintensity on Diffusion-Weighted Imaging in a MELAS Patient Does Not Necessarily Mean Cytotoxic Edema.

Journal of child neurology·2026
Same journal

Neuromuscular Symptoms of <i>ORAI1</i>-Related Immunodeficiency.

Journal of child neurology·2026
Same journal

Symptoms of Obsessive-Compulsive Disorder, Attention-Deficit/Hyperactivity Disorder, and Autism Spectrum Disorder in Children and Adolescents Attending a Headache Outpatient Clinic and School-Based Controls.

Journal of child neurology·2026
Same journal

Acute Encephalopathy From Central Nervous System Hemophagocytic Lymphohistiocytosis (CNS HLH) in X-Linked Lymphoproliferative Disease Type 1 (XLP-1).

Journal of child neurology·2026
Same journal

The Cost of Fear for Pediatric Neurologic Care.

Journal of child neurology·2026
See all related articles

Multiple sclerosis (MS) in Black children is rare but presents aggressively. This study highlights severe symptoms and rapid progression in pediatric MS cases.

Area of Science:

  • Neurology
  • Pediatrics
  • Immunology

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Pediatric MS (multiple sclerosis) is uncommon, with limited data on its presentation in minority populations.
  • Understanding early-onset MS is crucial for timely diagnosis and management.

Observation:

  • Six cases of childhood multiple sclerosis (MS) in Black children from the Washington, DC area were analyzed.
  • Patients aged 8–17 years presented with motor deficits, optic neuritis, and ataxia.
  • Prominent mental symptoms and an intractable disease course were noted.

Findings:

  • The pediatric MS cases exhibited a high frequency of relapses with short remissions and rapid progression.

Related Experiment Videos

  • Within 1–7 years, outcomes included death, severe disability, or steroid dependency with recurrent relapses.
  • The clinical course appeared more malignant than previously reported in pediatric MS.

    • Implications:

    • Multiple sclerosis (MS) does occur in Black children, challenging previous assumptions of rarity.
    • The aggressive nature of pediatric MS in this cohort necessitates further research into its unique characteristics.
    • Early detection and aggressive treatment strategies may be vital for improving outcomes in childhood MS.