Related Experiment Video

Updated: Jul 5, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

Inhibition of photocarcinogenesis by platelet-activating factor or serotonin receptor antagonists

Coimbatore S Sreevidya1, Noor M Khaskhely, Atsushi Fukunaga

  • 1Department of Immunology and the Center for Cancer Immunology Research, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

Cancer Research
|May 17, 2008
PubMed

Insights

Blocking platelet-activating factor (PAF) and serotonin (5-HT2A) receptors significantly reduced nonmelanoma skin cancer development in mice exposed to UV radiation. These antagonists also reversed UV-induced skin damage and immune suppression.

Area of Science:

  • Dermatology
  • Immunology
  • Oncology

Background:

  • Ultraviolet (UV) radiation from sunlight is a major cause of nonmelanoma skin cancer and immune suppression.
  • UV-induced immune suppression involves platelet-activating factor (PAF) binding to its receptor and cis-urocanic acid binding to the serotonin (5-HT2A) receptor.

Purpose of the Study:

  • To test if blocking PAF and 5-HT2A receptors prevents UV-induced skin cancer.
  • To investigate the role of these receptors in UV-induced skin damage and immune suppression.

Main Methods:

  • Hairless mice were injected with PAF or 5-HT2A receptor antagonists.
  • Mice were exposed to solar-simulated UV radiation.
  • Skin cancer incidence, progression, and UV-induced damage (hypertrophy, sunburn cells, apoptosis) were assessed.

Main Results:

  • Mice treated with PAF or 5-HT2A antagonists showed significantly reduced skin cancer incidence and progression.
  • Combined antagonist treatment demonstrated a synergistic effect in blocking cancer induction.
  • UV-induced skin damage, including hypertrophy, sunburn cell formation, and apoptosis, was significantly decreased by antagonist treatment.

Conclusions:

  • Blocking PAF and 5-HT2A receptors effectively inhibits UV-induced skin cancer development in vivo.
  • These antagonists mitigate UV-induced skin damage and prevent immune suppression, offering a potential therapeutic strategy.

More Related Videos

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Published on: December 19, 2019

Related Concept Videos

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...