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Published on: April 1, 2019

The genetics of carotid dissection: meta-analysis of a MTHFR/C677T common molecular variant

Peter McColgan1, Pankaj Sharma

  • 1Imperial College Cerebrovascular Research Unit (ICCRU), Department of Clinical Neuroscience, Imperial College London & Hammersmith Hospitals, London, UK.

Cerebrovascular Diseases (Basel, Switzerland)
|May 17, 2008
PubMed

Insights

This genetic meta-analysis found no link between the MTHFR C677T gene variant and carotid dissection. The study suggests homocysteine may not be a major factor in this stroke cause.

Area of Science:

  • Genetics
  • Neurology
  • Cardiovascular Science

Background:

  • Carotid dissection is a known cause of stroke.
  • Elevated homocysteine levels are linked to carotid dissection.
  • Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism influences homocysteine levels.

Purpose of the Study:

  • To conduct a comprehensive genetic meta-analysis.
  • To investigate the association between MTHFR C677T polymorphism and carotid dissection.

Main Methods:

  • Systematic review of case-control studies.
  • Meta-analysis of MTHFR C677T polymorphism in carotid dissection.
  • Calculation of pooled odds ratios (ORs) and confidence intervals (CIs) for genetic models.

Main Results:

  • Four studies with 420 participants (183 cases, 237 controls) were analyzed.
  • No significant association found for dominant (OR 1.36) or recessive (OR 1.07) MTHFR C677T models.
  • Comparison of homozygous genotypes (CC vs. TT) also showed no significant association (OR 0.73).

Conclusions:

  • The MTHFR C677T variant is not associated with carotid dissection.
  • Homocysteine is unlikely to be a major contributor to carotid dissection based on these findings.
Abstract

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