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[Disseminated and fatal adenovirus infection in an immunocompromised child]

Katia Abarca V1, Nicole Le Corre P, Cecilia Perret P

  • 1Escuela de Medicina, Departamento de Pediatría, Pontificia Universidad Católica de Chile, Chile. katia@med.puc.cl

Revista Chilena De Infectologia : Organo Oficial De La Sociedad Chilena De Infectologia
|May 17, 2008
PubMed

Insights

Severe adenovirus (ADV) infections are a critical concern in immunocompromised children, particularly after stem cell transplants. This case highlights a fatal disseminated ADV infection in a pediatric transplant recipient, emphasizing the need for prompt diagnosis and available treatments.

Area of Science:

  • Pediatric Hematology Oncology
  • Infectious Diseases
  • Virology

Background:

  • Adenovirus (ADV) infections pose significant risks to immunocompromised individuals, especially pediatric stem cell transplant (SCT) recipients.
  • Disseminated ADV infections can lead to severe morbidity and mortality in this vulnerable population.

Observation:

  • A 12-year-old SCT recipient developed a fatal disseminated adenovirus infection.
  • Diagnosis was confirmed through viral isolation and genome detection in blood and tissues.

Findings:

  • The case underscores the challenges in diagnosing and managing severe ADV infections in pediatric SCT patients.
  • Review of infection, diagnosis, and therapeutic options for ADV is presented.

Implications:

  • Clinicians should maintain a high index of suspicion for ADV in high-risk pediatric patients.
  • This case highlights the critical need for accessible antiviral therapies for ADV in regions like Chile.

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