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Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

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Related Experiment Video

Updated: Jul 5, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

[Pathogenesis of chronic wounds].

K Riedel1, H Ryssel, E Koellensperger

  • 1Klinik für Hand-, Plastische und Rekonstruktive Chirurgie, Schwerbrandverletztenzentrum, BG-Unfallklinik Ludwigshafen, Plastische und Handchirurgie der Universität Heidelberg, Ludwigshafen, Deutschland. k_riedel1@gmx.de

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|May 17, 2008
PubMed
Summary

Chronic wounds significantly impact quality of life and pose economic burdens. Understanding factors inhibiting wound healing is key to developing innovative therapies for nonhealing wounds.

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A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection

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Protocol to Create Chronic Wounds in Diabetic Mice
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A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection
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Area of Science:

  • Biomedical Science
  • Wound Healing Research
  • Regenerative Medicine

Context:

  • Chronic, nonhealing wounds present a significant medical and economic challenge, affecting patient quality of life.
  • Basic research has elucidated key mechanisms regulating wound healing processes.
  • Existing therapies often fall short for chronic wound management.

Purpose:

  • To review intrinsic and extrinsic factors that impede physiological wound healing, leading to chronic nonhealing wounds.
  • To explore molecular intervention strategies for enhancing wound repair.
  • To provide a foundation for developing novel therapeutic approaches.

Summary:

  • This review examines critical factors, both internal and external, that disrupt normal wound healing, resulting in chronic conditions.
  • It details molecular-level interventions targeting diverse pathways involved in tissue repair.
  • The paper synthesizes current knowledge on wound healing impediments and therapeutic innovations.

Impact:

  • Informs the development of targeted therapies for chronic nonhealing wounds.
  • Contributes to improving patient outcomes and reducing the economic burden of wound care.
  • Advances the field of regenerative medicine through a deeper understanding of wound repair mechanisms.