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Updated: Jul 5, 2026

A Microfluidic Chip for ICPMS Sample Introduction
11:16

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

Sample concentration and impedance detection on a microfluidic polymer chip.

Poorya Sabounchi1, Alfredo M Morales, Pierre Ponce

  • 1Energy Systems Department, Sandia National Laboratories, Livermore, CA, USA.

Biomedical Microdevices
|May 20, 2008
PubMed
Summary
This summary is machine-generated.

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This study introduces a microfluidic device using insulator-based dielectrophoresis (iDEP) to concentrate microparticles. This system enables selective detection and acts as a cost-saving front-end for biodetection systems.

Area of Science:

  • Microfluidics
  • Biotechnology
  • Analytical Chemistry

Background:

  • Microparticle analysis is crucial for diagnostics.
  • Current biodetection systems can be costly due to continuous reagent use.
  • A need exists for efficient sample preparation and analysis triggering.

Purpose of the Study:

  • To develop an on-chip microfluidic system for microparticle concentration and detection triggering.
  • To integrate insulator-based dielectrophoresis (iDEP) with electrical impedance measurement.
  • To create a cost-effective front-end for biodetection systems.

Main Methods:

  • Utilized insulator-based dielectrophoresis (iDEP) for selective microparticle concentration in a primary channel.
  • Integrated electrical impedance measurement with embedded electrodes in a side channel for detection.

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Last Updated: Jul 5, 2026

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Published on: March 5, 2015

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  • Demonstrated iDEP in the presence of pressure-driven flow for the first time.
  • Tested the system with polystyrene microspheres and Bacillus subtilis spores.

    • Main Results:

    • Successfully demonstrated selective iDEP trapping of microparticles.
    • Achieved electrical impedance detection of concentrated microparticles.
    • Showcased the system's ability to concentrate and divert samples for analysis.
    • Validated the platform's performance with model microparticles and spores.

    Conclusions:

    • The developed microfluidic platform effectively concentrates and triggers detection of microparticles.
    • This system offers a novel front-end solution to reduce operational costs of biodetection assays.
    • The integration of iDEP and impedance measurement provides a versatile tool for microparticle analysis.