Related Experiment Videos
Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production
P H Naccache1, M Grimard, C J Roberge
1Départment de Médicine, Université Laval, Ste Foy, Quebec, Canada.
Arthritis and Rheumatism
|March 1, 1991
Abstract:
The effects of monosodium urate and calcium pyrophosphate dihydrate crystals on the levels of cytoplasmic free calcium and on the oxidative burst in normal human blood neutrophils were examined. The pattern of sensitivity to granulocyte-macrophage colony-stimulating factor, colchicine, cytochalasin B, pertussis toxin, diglyceride kinase, and protein kinase C inhibitors differentiated the mechanism(s) of neutrophil activation by the crystals from that involved in the responses to soluble chemotactic factors and indicated that individual crystals can use several activation pathways.