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Updated: Jul 5, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

A case of livedoid vasculopathy associated with factor V Leiden mutation: successful treatment with oral warfarin

Mukaddes Kavala1, Emek Kocaturk, Ilkin Zindanci

  • 1Goztepe Training and Research Hospital, Department of Dermatology, Istanbul, Turkey.

The Journal of Dermatological Treatment
|May 20, 2008
PubMed

Livedoid vasculopathy is characterized by painful purpuric lesions on the extremities which frequently ulcerate and heal with atrophic scarring. It has been considered to be a vasculitic process but now there has been increasing evidence that abnormal coagulation plays a major role in the pathogenesis of this rare disorder. We report the case of a 19-year-old male who had been suffering from recurrent painful ulcerations on both lower legs with atrophic scars for 4 years. A biopsy specimen revealed vasculopathy, and laboratory studies showed resistance to activated protein C with factor V Leiden mutation. Treatment with oral warfarin led to rapid improvement of the lesions.

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