Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mutations01:39

Mutations

Overview
Mutations01:39

Mutations

Overview
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Mutations in Microorganisms01:18

Mutations in Microorganisms

Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative in vitro evaluation of fourth-generation anti-GPC3 CAR T-cells in hepatocellular carcinoma.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Next-generation of mesothelin-targeted CAR-T cells secreting anti-PD-L1 scFv for potent immunotherapy against 3D patient-derived colorectal cancer organoids.

BMC medicine·2026
Same author

Readmission and survival of hospitalized pulmonary tuberculosis patients: a nationwide record-based cohort analysis in Thailand (2017-2022).

Infectious diseases of poverty·2026
Same author

Change of substance-related hospitalisation in adolescents after cannabis legalisation in Thailand in 2022.

Addiction (Abingdon, England)·2026
Same author

Genetic determinants of drug-induced gingival overgrowth.

Scientific reports·2026
Same author

WGS identifies Lynch syndrome (LS) patients and uncovers a large family with MSH2-related LS in Southern Thailand.

PloS one·2026

Related Experiment Video

Updated: Jul 5, 2026

Identifying Mutations by High Resolution Melting in a TILLING Population of Rice
06:10

Identifying Mutations by High Resolution Melting in a TILLING Population of Rice

Published on: September 2, 2019

Thailand mutation and variation database (ThaiMUT).

Uttapong Ruangrit1, Metawee Srikummool, Anunchai Assawamakin

  • 1Biostatistics and Informatics Laboratory, Genome Institute, National Center for Genetic Engineering and Biotechnology (BIOTEC), Pathumtani, Thailand.

Human Mutation
|May 20, 2008
PubMed
Summary
This summary is machine-generated.

Researchers developed the Thailand Mutation and Variation database (ThaiMUT) to track genetic mutations in the Thai population. This resource aids in understanding Mendelian diseases and supports pharmacogenomic research.

More Related Videos

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Related Experiment Videos

Last Updated: Jul 5, 2026

Identifying Mutations by High Resolution Melting in a TILLING Population of Rice
06:10

Identifying Mutations by High Resolution Melting in a TILLING Population of Rice

Published on: September 2, 2019

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Area of Science:

  • Genomics and Bioinformatics
  • Human Genetics
  • Medical Informatics

Background:

  • The completion of the human genome project spurred advancements in sequencing and genotyping technologies for mutation detection.
  • Mutation spectra vary across ethnic groups, influencing the prevalence of Mendelian diseases.
  • Disparities in Mendelian disease occurrence exist globally and between ethnic groups.

Purpose of the Study:

  • To establish a National and Ethnic Mutation Database (NEMDB) specifically for the Thai population.
  • To provide web-based access to genetic mutation and variation data for Thai individuals.
  • To create an informatics tool for both research and clinical applications involving human variation data.

Main Methods:

  • Compilation of mutation data from PubMed and local Thai publications.
  • Inclusion of genetic polymorphisms in drug-related genes.
  • Development of a web-based platform for data access and deposition (ThaiMUT).

Main Results:

  • The Thailand Mutation and Variation database (ThaiMUT) was established, offering access to genetic mutation and variation information in the Thai population.
  • The database includes data on mutations causing Mendelian diseases and genetic polymorphisms in drug-related genes.
  • ThaiMUT serves as a valuable resource for retrieving and depositing human variation data.

Conclusions:

  • The ThaiMUT database is a crucial informatics tool for advancing research and clinical services in Thailand.
  • It supports clinical mutation screening for Mendelian diseases and facilitates pharmacogenomic research.
  • The database enhances understanding of genetic variations within the Thai population.