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Related Experiment Video

Updated: Jul 5, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Vascular changes in hepatocellular carcinoma.

Zhen Fan Yang¹, Ronnie T P Poon

¹Centre for Cancer Research, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.

Anatomical Record (Hoboken, N.J. : 2007)

|May 20, 2008

Summary

Hepatocellular carcinoma (HCC) angiogenesis is driven by vascular endothelial growth factor (VEGF). Blocking VEGF pathways shows promise for treating HCC, a highly vascular tumor.

Area of Science:

Oncology
Vascular Biology
Hepatology

Background:

Hepatocellular carcinoma (HCC) is a highly vascular tumor where angiogenesis is crucial for progression.
Angiogenesis status in HCC impacts disease advancement and patient outcomes, presenting a therapeutic target.
Understanding the vascular changes and molecular drivers of angiogenesis in HCC is key.

Purpose of the Study:

To review vascular changes and the molecular/cellular basis of angiogenesis in HCC.
To highlight the role of vascular endothelial growth factor (VEGF) in HCC angiogenesis.
To discuss the potential of anti-angiogenic therapies for HCC treatment.

Main Methods:

Review of scientific literature on HCC angiogenesis.
Analysis of molecular and cellular mechanisms driving vascularization in HCC.

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Examination of therapeutic strategies targeting angiogenesis.

Main Results:

HCC exhibits arterialization and sinusoidal capillarization.
VEGF is a critical mediator of angiogenesis in HCC, acting on various cell types.
VEGF pathway blockade suppresses HCC carcinogenesis and angiogenesis.
Other angiogenic factors interact with VEGF or act independently.

Conclusions:

Anti-angiogenic therapies targeting VEGF are a promising novel treatment for HCC.
Targeting angiogenesis offers a potential therapeutic avenue for HCC, despite treatment challenges.
Further research into angiogenic factors and their pathways is warranted for HCC management.