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A new disease activity index for rheumatoid arthritis: Mean Overall Index for Rheumatoid Arthritis (MOI-RA)

Heidi Mäkinen1, Hannu Kautiainen, Pekka Hannonen

  • 1Jyväskylä Central Hospital, Jyväskylä, Finland. heidi.makinen@ksshp.fi

The Journal of Rheumatology
|May 20, 2008
PubMed
Abstract

Insights

The Mean Overall Index for Rheumatoid Arthritis (MOI-RA) is a new, simple index for measuring rheumatoid arthritis disease activity. It effectively assesses treatment response in clinical trials and patient care.

Area of Science:

  • Rheumatology
  • Clinical Trial Design
  • Biostatistics

Background:

  • Rheumatoid arthritis (RA) disease activity assessment relies on composite indices.
  • Existing indices may have limitations in simplicity or feasibility for continuous monitoring.
  • The American College of Rheumatology (ACR) core data set provides key measures for RA assessment.

Purpose of the Study:

  • To develop and validate a continuous composite index for RA disease activity.
  • The index, Mean Overall Index for Rheumatoid Arthritis (MOI-RA), is based on the ACR core data set.
  • To evaluate MOI-RA's feasibility and measurement properties in a clinical trial setting.

Main Methods:

  • MOI-RA was constructed by standardizing and averaging 7 ACR core data set components.
  • Components include joint counts, physical function, patient/physician global assessments, pain, and ESR.
  • Validity and measurement properties were assessed in 169 RA patients in the Finnish RA Combination therapy trial.

Main Results:

  • MOI-RA demonstrated significant decrease, indicating treatment response, comparable to DAS28.
  • High correlation (0.90) was observed between MOI-RA28 and DAS28.
  • MOI-RA showed excellent reproducibility (0.97) and robustness to missing data (ICC 0.98).

Conclusions:

  • MOI-RA is a simple and feasible composite index for assessing RA disease activity.
  • It utilizes the established ACR core data set measures.
  • MOI-RA is suitable for use in RA clinical trials and routine clinical practice for monitoring treatment response.

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