Related Experiment Video
Updated: Jul 5, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
DRD3 Ser9Gly variant is not associated with essential tremor in a series of Italian patients
1Department of Neurological Sciences, Institute of Diagnosis e Therapy, University Federico II, Naples.
Background:
Essential tremor (ET) is the most common movement disorder worldwide. Three susceptibility loci on chromosomes 3q13, 2p24.1, and 6p23 have been reported, but no causative genes were found. The Ser9Gly variant of dopamine D3 receptor (DRD3) receptor was found associated to ET in a French and US population.
Methods:
A case-control study to evaluate the association between the Ser9Gly variant and ET was performed in a cohort of 116 Italian patients with familial ET and in 158 normal controls.
Results:
No significant difference in allele and genotype frequencies was found between the two groups.
Conclusions:
These results do not support an association between DRD3 Ser9Gly and susceptibility to ET in Italian patients.
Related Concept Videos
Alterations in Muscle Tone lll
Parkinson Disease ll: Pathophysiology
Parkinson Disease l: Introduction
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Huntington Disease l: Introduction
Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life

