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Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

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Reference values for clinical chemistry tests during normal pregnancy.

A Larsson¹, M Palm, L-O Hansson

¹Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden. anders.larsson@akademiska.se

BJOG : an International Journal of Obstetrics and Gynaecology

|May 20, 2008

Summary

This summary is machine-generated.

Establishing pregnancy-specific reference values for laboratory tests is crucial, as most analytes change significantly during gestation. This study provides essential reference intervals for 25 common laboratory markers in normal pregnancies.

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Area of Science:

Clinical Chemistry
Obstetrics
Laboratory Medicine

Background:

Standard laboratory reference values are typically based on non-pregnant individuals, which is suboptimal for pregnant women.
Biological markers often change significantly during pregnancy, necessitating pregnancy-specific reference ranges.
Limited data exists on laboratory test variations during early and mid-pregnancy.

Purpose of the Study:

To establish reference values for frequently used laboratory tests during normal pregnancy.
To address the need for accurate clinical decision-making based on pregnancy-specific laboratory data.

Main Methods:

Longitudinal study involving 52 healthy pregnant females.
Analysis of 25 laboratory tests with samples collected up to nine times per woman.
Data grouped by gestational periods from 7 weeks to postpartum, with 2.5 and 97.5 percentiles calculated.

Main Results:

Reference intervals were determined for 25 analytes, including liver enzymes, lipids, electrolytes, and hormones.
Significant variations were observed for most analytes across different pregnancy stages.
Specific reference intervals are provided for gestational weeks 7-17, 17-24, 24-28, 28-31, 31-34, 34-38, predelivery, and postpartum.

Conclusions:

Most laboratory analytes undergo significant changes during normal pregnancy.
The use of pregnancy-specific reference values is essential for accurate interpretation of laboratory results.
This study provides a valuable resource for clinical practice in obstetrics and laboratory medicine.