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Related Experiment Video

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5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

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Published on: April 4, 2025

Feasibility and outcomes of repeat partial nephrectomy.

Aaron Johnson¹, Sunil Sudarshan, Jack Liu

¹Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1107, USA.

The Journal of Urology

|May 20, 2008

Summary

Repeat partial nephrectomy is feasible for hereditary renal cancer recurrence. While it causes a slight decrease in kidney function, most patients avoid dialysis and achieve acceptable oncological control.

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A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

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Published on: July 18, 2025

Area of Science:

Urology
Oncology
Nephrology

Background:

Hereditary renal cancer patients face high recurrence risk after nephron sparing surgery.
Management options for recurrent renal tumors include repeat partial nephrectomy, ablation, or completion nephrectomy.

Purpose of the Study:

To evaluate the feasibility and outcomes of repeat partial nephrectomy on the same kidney unit.
To assess oncological control and renal function after repeat partial nephrectomy.

Main Methods:

Retrospective review of 51 repeat partial nephrectomy procedures in 47 patients (1992-2006).
Collected demographic, intraoperative, perioperative, and renal functional outcome data.
Compared pre- and post-operative renal function using a 2-tailed t-test.

Main Results:

19.6% of cases had major complications or reoperations, with 1.9% perioperative mortality.
Successful repeat partial nephrectomy led to increased serum creatinine and decreased creatinine clearance and renogram split function (p<0.05).
3.9% required long-term hemodialysis; 19.6% needed further surgery for recurrence or new tumors. 98% of patients survived at median follow-up.

Conclusions:

Repeat partial nephrectomy is technically feasible for recurrent renal tumors.
Despite functional decline, most patients maintain adequate kidney function, avoiding dialysis.
This procedure offers acceptable oncological outcomes for recurrent or de novo renal tumors.