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Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Mastoid obliteration using calcium phosphate bone paste with an artificial dermis soaked with basic fibroblast growth
Akinobu Kakigi1, Daizo Taguchi, Taizo Takeda
1Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi 783-8505, Japan. kakigia@kochi-u.ac.jp
Objectives:
To describe mastoid obliteration using a calcium phosphate paste with an artificial dermis soaked with basic fibroblast growth factor (b-FGF) and the usefulness of this procedure.
Methods:
Ten ears that underwent a canal wall-down mastoidectomy were treated with calcium phosphate paste. The cases consisted of four patients with mastoid cavity problem, four with middle ear cholesteatoma, one with adhesive otitis media, and one with external auditory canal cholesteatoma. The post-operative follow-up period was 19.9 months on average (ranging from 13 to 23 months). First, the canal wall-down mastoidectomy was performed. Then, the calcium phosphate paste was used to fill up to the facial ridge posteriorly and the horizontal segment of the facial canal superiorly. The surface of the paste was covered with an artificial dermis soaked with b-FGF.
Results:
Following calcium phosphate paste treatment, all open cavities were decreased in volume and epithelized within 2 months.
Conclusion:
Calcium phosphate paste appears effective for mastoid obliteration. Using an artificial dermis soaked with b-FGF appears to prevent exposure of the paste to the skin of the external auditory meatus. However, the number of the patients is too small to draw any conclusion.
